Research in the Argraves laboratory has been supported by:         

• Scientist Development Grant 0230245N (Argraves, P.I.)             1/01/02 - 12/31/06
  
American Heart Association-Jon DeHaan Foundation Scientist Development Grant in Angiogenesis
The Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis

The major goals of this project are to determine if sphingosine-1-phosphate is the vasculogenic component of serum and to determine which of its receptors are critical for this process.

 

• R01 HL080404 (Argraves, PI)                                                   07/15/05 - 05/31/10
NIH/NHLBI
Sphingosine-1-Phosophate Signaling in Vasculogenesis

The major goal of this project is to understand the mechanisms by which SIP signaling influences angioblast motility and to establish its in vivo relevance in the context of physiological and pathological neovascular processes that involve adult vasculogenesis including tumor formation, wound healing and myocardial infarction.



• P20 RR17677 (Obeid, P.I./Argraves, Project 1 Leader)               09/30/02 - 08/31/07
  
NIH/NCRR COBRE in Lipidomics and Pathobiology  
Role of Sphingosine-1-Phosphate in Early Blood Vessel Formation

The major goals of this project are for further mentoring and to identify the growth or behavior characteristics of endothelial cells and mural cells or their mesodermal progenitors for which sphingosine-1-phosphate signaling is critical.